PRP TREATMENT IN GLENVIEW · CHICAGO AREA
Your biology.
Your active life.
A personalized, nonsurgical option for joint pain and select soft-tissue conditions—built around how you want to move, feel, and live.
Active longevity. Joint preservation. Personalized care.
Platelet-Rich Plasma Therapy
PRP therapy harnesses the concentrated healing power of your own blood platelets to support recovery and help restore function — without surgery.
The PRP Process
Blood Draw
A small sample of your blood is drawn from your arm, just like a routine blood test.
Centrifugation
Your blood is spun at high speed to separate and concentrate the platelet-rich plasma from other components.
Targeted Injection
The prepared PRP is injected into the selected joint, tendon, or tissue, with imaging guidance when appropriate.
Healing & Recovery
Platelet growth factors deliver signals involved in your body’s repair response. Follow-up and rehabilitation support your recovery goals.
Platelet-Rich Plasma (PRP) is a concentrated preparation derived from your own blood. Blood naturally contains platelets — tiny cells that play a critical role in clotting and healing. Platelets carry hundreds of proteins called growth factors that orchestrate tissue repair at the cellular level.
Autologous treatment: PRP is prepared from your own blood and concentrates your own platelets.
Concentrated healing signals: Platelets release growth factors involved in repair. Platelet dose and preparation are important topics to discuss with your clinician.
Evidence-informed care: Clinical research examines PRP for joint and tendon conditions, including pain and functional outcomes in knee osteoarthritis.
Minimally invasive: Blood collection, preparation, and injection take place in an office setting, without a surgical incision.
Blood Composition After Centrifugation
The buffy coat layer — containing platelets and white blood cells — is isolated and further processed to create injectable PRP concentrate.
ReGen360 uses PRP as a nonsurgical option within an individualized plan for joint and tendon concerns. The research comparison below focuses on knee osteoarthritis, where PRP has been studied for pain relief and improved function.
On a small screen, swipe across the table to compare all options.
| Consideration | PRP at ReGen360 | Corticosteroid injection | Physical therapy |
|---|---|---|---|
| Treatment focus | Uses platelets from your own blood to support biological repair signaling. ReGen360’s treatment goals include improved comfort, mobility, and everyday function. | Delivers anti-inflammatory medication into the joint to relieve symptoms. | Builds strength, movement confidence, and function through individualized exercise. |
| Pain and function | Meta-analyses report meaningful improvements in knee osteoarthritis pain and function compared with placebo. [1] [2] | Can provide short-term pain relief, helping some patients participate in rehabilitation. | Exercise-based care is an important part of knee osteoarthritis management. |
| Patient selection | Earlier-stage knee osteoarthritis showed higher response rates in a clinical cohort. Your ReGen360 evaluation considers diagnosis, imaging, symptoms, and activity goals. [3] | Selection considers symptoms, prior response, injection frequency, and medical history. | The program is adapted to your strength, movement, symptoms, and health. |
| Preparation and duration | Platelet concentration can influence outcomes. Higher-concentration study groups showed sustained benefits through 12 months; discuss the preparation and plan suited to your condition. [1] | Duration varies. Follow-up helps determine whether another injection is appropriate. | Progressive exercise and continued participation support ongoing function. |
| Repeated treatment | PRP planning can include a series of injections and follow-up, tailored to the condition and clinical response. | Repeated use warrants care: a 2-year trial of 40 mg triamcinolone every 3 months found greater cartilage loss than saline, without better pain outcomes. This finding concerns that specific regimen. [5] | Exercises are progressed and adapted over time as strength and function improve. |
| Diabetes considerations | PRP itself is a steroid-free blood preparation. Your clinician reviews glucose control, medications, and overall suitability before treatment. | Can temporarily raise blood glucose, often 24–72 hours after injection. People with diabetes should arrange monitoring and medication guidance with their clinician. [6] | Exercise and activity plans can be coordinated with diabetes management. |
| Tolerability and aftercare | Generally well tolerated in reviewed trials, with reported reactions mainly temporary local discomfort. ReGen360 provides an individualized aftercare and follow-up plan. [4] | Temporary injection-site discomfort can occur. Review risks, repeat exposure, and aftercare with the clinician. | Activity is adjusted to keep exercise appropriate for symptoms and recovery. |
| Costs and coverage | Ask ReGen360 for an individualized plan and written estimate. Orthopedic PRP is often self-pay. | Coverage and out-of-pocket costs depend on the insurance plan and indication. | Coverage, visit limits, and out-of-pocket costs depend on the insurance plan. |
These findings describe published study populations, not measured ReGen360 outcomes. Results vary by condition, preparation, and patient. See the risks and safety section for injection precautions.
PRP, injections, and rehabilitation can play different roles in a care plan. Explore our regenerative medicine treatment categories or discuss your goals with ReGen360.
When platelets are activated, they release growth factors involved in cell signaling and repair. PRP concentrates these signals at the treatment site with the aim of supporting your body’s healing response. Explore the biology of PRP with Stanford Health Care.
Activated platelets release growth factors such as PDGF, TGF-β, and VEGF. These proteins help cells communicate during the response to injury.
Growth factors participate in fibroblast activity and the production of collagen and extracellular matrix. PRP aims to support these repair processes; clinical improvement does not by itself establish that cartilage or a damaged tendon has regrown.
Platelet signals participate in blood vessel formation and the regulation of inflammation. These biological mechanisms help explain the rationale for PRP treatment and remain an active area of research.
01
PRP offers a nonsurgical treatment option for selected joint and tendon concerns. The goal is meaningful pain relief and functional improvement within a plan matched to your diagnosis.
02
PRP uses a concentrated preparation of your own blood platelets. This autologous approach brings your own biological repair signals to the treatment area.
03
PRP aims to support the biological processes involved in tissue repair, with the goal of lasting improvements in comfort and function. Whether it is appropriate depends on the cause of your symptoms and your examination.
04
Blood collection, preparation, and injection are completed during an office visit. Your team will explain appointment length, comfort measures, and when you can return to light activity.
05
PRP can be incorporated into a broader plan that includes physical therapy, progressive strengthening, and activity modification to support recovery and mobility.
06
Published knee osteoarthritis research reports sustained improvements in pain and function, including benefits at 12 months in some study groups. Review the 2025 meta-analysis. Duration varies with the condition, preparation, and individual response.
Explore the benefits and limitations of PRP therapy to understand potential outcomes, factors that influence results, and what to expect from treatment.
PRP is considered for a range of joint and soft-tissue concerns. At ReGen360, the consultation connects your diagnosis and activity goals with the evidence relevant to your condition. Explore PRP applications with HSS.
Tendon
Commonly known as “tennis elbow,” this persistent tendon problem is one of the conditions studied for PRP. Evaluation includes your symptoms, previous care, and rehabilitation goals.
Tendon
Patellar and Achilles tendon problems are evaluated individually. PRP may be discussed as part of a plan to improve comfort and function alongside appropriate tendon rehabilitation.
Knee
Intra-articular PRP has shown pain and functional benefits in studies of knee osteoarthritis. A 2026 meta-analysis reported improvements compared with placebo. The findings support a discussion of symptom relief; they do not establish cartilage regrowth.
Plantar
For persistent plantar heel pain, PRP may be considered after diagnosis and a review of footwear, activity modification, stretching, and other conservative care.
Rotator Cuff
PRP is studied for selected rotator cuff conditions, including use during surgical repair. The care plan depends on the type of tendon problem and whether surgery is involved.
Hip
PRP may be discussed for gluteal tendinopathy and hip osteoarthritis. These are different conditions, so evaluation and treatment goals are specific to the diagnosis.
Spine
PRP is being studied for selected sources of chronic back pain. A specialist assessment helps determine the pain source and whether an injection is appropriate.
Ligament
For selected ligament injuries, PRP may be discussed as an adjunct to rehabilitation, with the goal of supporting recovery and a return to stable, confident movement. Injury severity guides the need for other treatment.
Muscle
For muscle injuries, PRP may be considered within an individualized rehabilitation plan focused on rebuilding strength and returning to activity. Recovery timing depends on the injury and clinical progress.
Before your appointment
Bring a list of medications and supplements, including aspirin, anti-inflammatory medicines, and blood thinners. Your clinician will give individualized instructions. Do not stop prescribed medication without guidance from the prescribing clinician.
Step 1 — 5–10 minutes
A venous blood draw is performed from your arm using a standard phlebotomy technique. The volume collected varies by system and condition, typically 15–60 mL. The blood is drawn into specialized collection tubes containing anticoagulant to prevent premature clotting.
Step 2 — 15–20 minutes
Your blood is placed in a medical-grade centrifuge and spun at a precisely calibrated speed. This separates the blood into layers by density. The technician carefully extracts the platelet-rich layer and may perform a second spin to further concentrate the platelets. The final PRP product is loaded into injection syringes.
Step 3 — 5–15 minutes
The target area is cleaned and a local anesthetic may be applied. Using real-time musculoskeletal ultrasound imaging, your physician visualizes the precise anatomical target — whether a tendon insertion, joint space, or bursa — and delivers the PRP with needle-tip accuracy. Ultrasound guidance significantly improves injection accuracy compared to landmark-based techniques.
Post-procedure
Your team will explain observation, pain management, activity limits, and follow-up for your procedure. Some soreness or swelling can occur. Ask which symptoms need prompt medical attention and whom to contact.
Recovery is a gradual process that combines aftercare, rehabilitation, and follow-up. The stages below describe the goals of recovery; timing is individualized to your condition and procedure.
After injection
Temporary soreness, swelling, or bruising may occur. Follow the care team’s instructions for comfort, activity, and medicines, and contact them if symptoms worsen or concern you.
Early recovery
Resume light activity and gentle movement according to your individualized plan. The treatment area and your symptoms guide progression.
Rehabilitation
Physical therapy and progressive loading can support strength, mobility, and a confident return to everyday activity. Your clinician will guide timing and intensity.
Follow-up
Follow-up assesses changes in pain, mobility, and activity. Published knee osteoarthritis studies report benefits over several months; additional treatment is considered according to your response.
Realistic Expectations
Response depends on the diagnosis, disease severity, preparation, and rehabilitation. In one 517-patient knee osteoarthritis study using three leukocyte-poor PRP injections, 12-month responder rates were 75.2% for KL grade 2 and 66.5% for grade 3. These are published study results, not ReGen360’s own success rates. Read the patient-selection study.
Using your own blood does not make an injection risk-free. Possible complications include infection, bleeding, and nerve or tissue injury, as well as a lack of benefit. Review PRP risks with Johns Hopkins Medicine.
Well-suited candidates
Patients with chronic musculoskeletal pain unresponsive to 3–6 months of conservative management (rest, physical therapy, oral medications)
Active adults who want to discuss evidence-based options for a specific tendon, ligament, or muscle condition
Patients with knee osteoarthritis who want to review options after an appropriate trial of conservative care
Those seeking to minimize reliance on corticosteroid injections, which carry risks of tissue damage with repeated use
Individuals who are not surgical candidates due to health status, age, or personal preference
Patients willing to commit to a structured post-injection rehabilitation program to optimize outcomes
Relative contraindications or poor candidates
Active systemic infection, septic arthritis, or localized skin infection at the injection site
Active malignancy, particularly hematologic cancers such as leukemia or lymphoma
Low platelet count or platelet dysfunction requiring clinical assessment
Use of anticoagulants or other medicines that require individualized risk assessment; do not stop them on your own
Advanced osteoarthritis that may need a different treatment or surgical evaluation
Patients with unrealistic expectations or unwillingness to modify activity and complete rehabilitation post-treatment
Understand how PRP is prepared, what the research shows, and what to discuss before treatment.
Reviewed by Shannon Patel
Clinical Director & Regenerative Medicine Specialist
Evin Koleini, MD
Anesthesiology and Interventional Pain Management
Regenerative Medicine
Platelet-rich plasma (PRP) is prepared from your own blood and contains a higher concentration of platelets. These platelets release growth factors involved in tissue repair and cell signaling. A clinician injects PRP into a selected area with the aim of improving symptoms and supporting healing.
PRP is a blood-derived treatment, not a stem cell treatment. Its effects depend on the condition being treated and the preparation used.
PRP may improve pain and function for some people with knee osteoarthritis, but study results are mixed. Some randomized trials report benefits compared with saline injections; others do not. Improvement in symptoms does not establish that PRP rebuilds cartilage or reverses arthritis.
For example, the RESTORE trial found no significant advantage over saline for pain or cartilage volume at 12 months. A separate multicenter trial reported better pain and function with PRP. These differences make an individual assessment and realistic expectations essential.
PRP is studied and used for selected tendon and joint conditions, including chronic tennis elbow. Evidence varies by diagnosis, and results for one tendon or joint should not be assumed to apply to every injury. A clear diagnosis should come before choosing an injection.
Your evaluation can help determine whether PRP, rehabilitation, another nonsurgical treatment, or a surgical opinion is appropriate.
Sources: [5]
A PRP appointment generally involves a blood draw, preparation in a centrifuge to concentrate the platelets, and an injection into the selected treatment area. Ultrasound may be used to guide placement. The clinician should explain the procedure, expected discomfort, and aftercare before treatment begins.
Appointment length and the need for imaging depend on the treatment area and clinical plan.
Sources: [1]
There is no single PRP injection schedule that is appropriate for every patient. Some treatment plans use one injection; others use a series. The number and spacing should reflect the diagnosis, evidence for that condition, and response to treatment.
Ask what improvement the proposed series is intended to achieve, when progress will be reviewed, and what would prompt a change in the plan.
Sources: [6]
PRP is not expected to provide immediate relief. When it helps, improvement may develop over several weeks. The amount and duration of benefit vary, and some patients do not improve. Benefits are not permanent or predictable, and additional treatment may be considered after reassessment.
Follow-up should assess pain, function, and activity goals before deciding whether additional treatment is worthwhile.
Temporary soreness, bruising, or swelling can occur after PRP. Less common risks include infection, bleeding, and injury to nearby tissue or nerves. Using your own blood does not make the procedure risk-free, and the treatment may not provide the hoped-for benefit.
Discuss your medical history and medications with the treating clinician. Obtain personalized preparation and aftercare instructions.
Coverage for musculoskeletal PRP is often limited, and many patients pay out of pocket. Benefits depend on the insurer, plan, and indication. Check directly with your insurer and ask the clinic for a written estimate before agreeing to treatment.
If you plan to use an HSA or FSA, confirm eligibility and documentation requirements with your account administrator.
ReGen360 · 847-243-6041
Explore these educational resources from Johns Hopkins Medicine, Stanford Health Care, and UCLA Health for additional perspectives on platelet-rich plasma and its use in musculoskeletal care.
Platelet-Rich Plasma (PRP) Injections
Explains how PRP is prepared from a patient’s own blood and discusses its use for tendon, ligament, muscle, and joint conditions. The overview also covers possible benefits, risks, and the developing evidence for osteoarthritis.
Read the PRP overview
hopkinsmedicine.org
Orthobiologics and Regenerative Medicine
Describes blood collection, centrifugation, and PRP injection, including the potential role of platelet growth factors in reducing pain and supporting healing. Stanford also notes that whether current orthobiologics restore damaged tissue to its preinjury state remains uncertain.
Explore PRP and orthobiologics
stanfordhealthcare.org
PRP in Sports Medicine
UCLA sports medicine specialists discuss PRP among the orthobiologic treatments used in care for athletes and active adults. The article describes its use for cartilage breakdown and tendinosis, along with improvements in separating platelets and other plasma components.
Read the sports medicine article
uclahealth.org
Independent educational resources. Inclusion does not imply affiliation with or endorsement of ReGen360. PRP evidence and outcomes vary by condition.
Links reviewed October 1, 2026. Sources open in a new tab.
Schedule a consultation with our sports medicine and regenerative medicine specialists. We’ll review your imaging, discuss your goals, and determine whether PRP is the right pathway for your recovery.
